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Quantitative imaging with fast fan-beam scan using a benchtop X-ray fluorescence computed tomography

Liang Li, Siyuan Zhang, Ruizhe Li, Zhiqiang Chen

DOI:10.12059/Fully3D.2017-11-3108006

Published in:Fully3D 2017 Proceedings

Pages:527-530

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Keywords:
X-ray fluorescence, computed tomography, nanoparticle (NP), image reconstruction, photon-counting detector
X-ray fluorescence computed tomography (XFCT) is a quantitative imaging technique which detects the characteristic X-ray photons from certain elements stimulated by an excitation source. Hence, it can reconstructs the two- (2D) or three-dimensional (3D) distribution of nonradioactive high atomic nanoparticles (NPs) within an organism, such as gold, gadolinium, and iodine. However, early XFCT performed on a high-intensity monochromatic synchrotron source with large facilities or a pencil beam collimated from a polychromatic X-ray tube with a very long scanning time. In this paper, we developed a fast full-field fan-beam XFCT on our SKYFI (simultaneous K-edge and X-ray fluorescence CT imaging) benchtop setting with a conventional low-intensity polychromatic X-ray tube, energy-sensitive photon-counting detector arrays and a tungsten pinhole collimator. A homemade phantom that contained gadolinium solutions was scanned for 30 min using a full-field fan-beam in the third-generation CT geometry. After accurate detector energy calibration, scattering and attenuation corrections, experimental results showed high sensitivity and accuracy. Therefore, this kind of full-field XFCT identifies a clear path toward for biomedical imaging of exogenous molecular NP probes.
Liang Li
Department of Engineering Physics, Tsinghua University, Beijing, 100084, China & Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education, 100084, China.
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Siyuan Zhang
Department of Engineering Physics, Tsinghua University, Beijing, 100084, China & Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education, 100084, China.
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Ruizhe Li
Department of Engineering Physics, Tsinghua University, Beijing, 100084, China & Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education, 100084, China.
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Zhiqiang Chen
Department of Engineering Physics, Tsinghua University, Beijing, 100084, China & Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education, 100084, China.
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