Interior Tomography Approach for MRI-guided Radiation Therapy

Xun Jia, Steve B. Jiang, Gary Pickrell, Ge Wang

DOI:10.12059/Fully3D.2017-11-3111004

Published in:Fully3D 2017 Proceedings

Pages:390-395

Keywords:
Image guidance plays a critical role in radiotherapy to ensure treatment accuracy. Cone-beam CT (CBCT) installed on a medical linear accelerator (LINAC) is routinely used in clinics for this purpose. While CBCT can provide an x-ray attenuation image to guide patient positioning, low soft-tissue contrast affects the delineation of anatomical features, hindering setup accuracy in many cases. To solve this problem, several MRI-LINAC systems have been developed to combine a full diagnostic MRI scanner with a radiotherapy machine. In this paper, we present a new concept for the development of the MRI-LINAC system. Instead of combining a full MRI scanner with the LINAC, we propose to use an interior MRI (iMRI) approach to image a specific region of interest (ROI) containing the radiation treatment target. The iMRI will offer local imaging of high soft-tissue contrast for tumor delineation. Meanwhile, megavoltage CBCT currently available on the LINAC will be used to deliver a global image of the patients anatomy. This paper describes a top-level iMRI system design and its integration to an LINAC platform. Preliminary studies on magnetic field design and imaging capability are also presented.
Xun Jia
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390
Steve B. Jiang
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390
Gary Pickrell
Department of Materials Science and Engineering, Virginia Tech Blacksburg, VA 24061
Ge Wang
Department of Biomedical Engineering, Rensselaer Polytechnic InstituteTroy, NY 12180
  1. T. Bortfeld, “Imrt: a review and preview,” Physics in Medicine and Biology, vol. 51, no. 13, p. R363, 2006. [Online]. Available: http://stacks.iop.org/0031-9155/51/i=13/a=R21
  2. D. W. Miller, “A review of proton beam radiation therapy,” Medical Physics, vol. 22, no. 11, pp. 1943–1954, 1995. [Online]. Available: http://dx.doi.org/10.1118/1.597435
  3. D. A. Jaffray, D. G. Drake, M. Moreau, A. A. Martinez, and J. W. Wong, “A radiographic and tomographic imaging system integrated into a medical linear accelerator for localization of bone and soft-tissue targets,” International Journal of Radiation Oncology*Biology*Physics, vol. 45, no. 3, pp. 773 – 789, 1999. [Online]. Available: http://www.sciencedirect.com/science/article/pii/S0360301699001182
  4. S. Mutic and J. F. Dempsey, “The viewray system: Magnetic resonanceguided and controlled radiotherapy,” Seminars in Radiation Oncology, vol. 24, no. 3, pp. 196 – 199, 2014, magnetic Resonance Imaging in Radiation Oncology. [Online]. Available: http://www.sciencedirect.com/science/article/pii/S1053429614000253
  5. J. J. W. Lagendijk, M. van Vulpen, and B. W. Raaymakers, “The development of the mri linac system for online mri-guided radiotherapy: a clinical update,” Journal of Internal Medicine, vol. 280, no. 2, pp. 203–208, 2016. [Online]. Available: http://dx.doi.org/10.1111/joim.12516
  6. B. G. Fallone, “The rotating biplanar linacmagnetic res-onance imaging system,” Seminars in Radiation Oncology, vol. 24, no. 3, pp. 200 – 202, 2014, magnetic Resonance Imaging in Radiation Oncology. [Online]. Available: http://www.sciencedirect.com/science/article/pii/S1053429614000289
  7. P. J. Keall, M. Barton, and S. Crozier, “The australian magnetic resonance imaginglinac program,” Seminars in Radiation Oncology, vol. 24, no. 3, pp. 203 – 206, 2014, magnetic Resonance Imaging in Radiation Oncology. [Online]. Available: http://www.sciencedirect.com/science/article/pii/S1053429614000320
  8. G. Wang and H. Yu, “The meaning of interior tomography,” Physics in Medicine and Biology, vol. 58, no. 16, p. R161, 2013. [Online]. Available: http://stacks.iop.org/0031-9155/58/i=16/a=R161
  9. M. Poole, P. Weiss, H. S. Lopez, M. Ng, and S. Crozier, “Minimax current density coil design,” Journal of Physics D: Applied Physics, vol. 43, no. 9, p. 095001, 2010.
  10. D. Homa, Y. Liang, C. Hill, G. Kaur, and G. Pickrell, “Superconducting tin core fiber,” Applied Physics A, vol. 118, no. 1, pp. 23–26, 2015.[Online]. Available: http://dx.doi.org/10.1007/s00339-014-8869-2
  11. D. Homa, G. Kaur, G. Pickrell, and Y. Liang, “Efficient cooling of superconducting fiber core via holey cladding,” Cryogenics, vol. 61, pp. 25 – 30, 2014. [Online]. Available: http://www.sciencedirect.com/science/article/pii/S0011227514000253
  12. P. Dong, P. Lee, D. Ruan, T. Long, E. Romeijn, D. Low, P. Kulelian, J. Abraham, Y. Yang, and K. Sheng, “4π noncoplanar stereotactic body radiation therapy for centrally located or larger lung tumors,” International Journal of Radiation Oncology Biology Physics, vol. 86, no. 3, pp. 406–417, 2013.