Excitation based cone-beam X-ray luminescence tomography of nanophosphors with different concentrations

Peng Gao, Huangsheng Pu, Junyan Rong, Wenli Zhang, Tianshuai Liu, Wenlei Liu, Hongbing Lu


Published in: Fully3D 2017 Proceedings


image reconstruction techniques, optical tomography, X-ray imaging, principal component analysis
Cone-beam X-ray luminescence computed tomography (CB-XLCT), which has been proposed as a new molecular imaging modality recently, can obtain both anatomical and functional tomographic images of an object efficiently, with the excitation of nanophosphors in vivo or in vitro by cone-beam X-rays. However, the ill-posedness of the CB-XLCT inverse problem degrades the image quality and makes it difficult to resolve adjacent luminescence targets with different concentrations, which is essential in drug delivery and treatment monitoring in vivo. To address this problem, a multi-voltage excitation imaging scheme combined with principal component analysis is proposed in this study. Imaging experiments performed on physical phantoms by a custom-made CB-XLCT system demonstrate that two adjacent targets, with the concentration differences of 50 and 100 mg/ml and an edge-toedge distance of 0 mm, can be effectively resolved.
Peng Gao
FMMU, China
Huangsheng Pu
FMMU, China
Junyan Rong
FMMU, China
Wenli Zhang
FMMU, China
Tianshuai Liu
FMMU, China
Wenlei Liu
FMMU, China
Hongbing Lu
FMMU, China
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