Keywords:
The conventional Dual-Head SPECT system for nuclear cardiac imaging suffered from low sensitivity. In this work we designed a high-sensitivity multi-pinhole SPECT system for dynamic studies. Two same flat collimators were placed with an angle 76◦. The diameter of pinholes was 4.5 mm and the analytical calculation of sensitivity across ∼ 18 cm of FOV was 0.06%, four times higher than Dual-Head LEHR SPECT (typically 0.015%). The high sensitivity was at the cost of the spatial resolution, about 12 mm (analytical) in this design. To accomplish resolution recovery, a new analytical pinhole model was derived and a Gaussian model was used in calculation of the system matrix. Monte Carlo simulation of point source and myocardium phantom were performed with GATE. MLEM was used for reconstruction of simulation data with analytical pinhole model. The δ model was also used for comparison. The point projection images obtained from analytical pinhole model were compared with the ones obtained from long-time GATE simulation. The new pinhole model reduced the FWHM of point source reconstruction results from 11.7 × 10.9 × 10.2 mm3 (Delta Model) to 3.4 × 3.7 × 3.0 mm3. Myocardium phantom studies showed good performance and defect identification. In conclusion, this multi-pinhole dynamic SPECT system had high sensitivity and the resolution recovery was accomplished. In further work, this design will be implemented on variable-angle dual-head SPECT ImageE NET 632 and more studies will be performed.
- Haipeng Wang
- Department of Engineering Physics, Tsinghua University Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of EducationKey Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education
- Hui Liu
- Department of Engineering Physics, Tsinghua University Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of EducationKey Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education
- Yaqiang Liu
- Department of Engineering Physics, Tsinghua University Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of EducationKey Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education
- Si Chen
- Beijing Novel Medical Equipment Ltd, Beijing, 100084, China.
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