Keywords:
The MARS programme is developing spectral CT scanners to advance medicine. Our system is built upon the Medipix3RX ASIC developed by a CERN led collaboration. The Medipix3RX has 8 counters where some counters use charge summing technology to improve energy resolution. Our scanners include small bore scanners, pre-clinical systems used by our partners at the Mayo Clinic, Notre Dame University, and the University of Otago, and a large bore scanner (a human scale system in development). In this talk we demonstrate some of the applications, and publicly available datasets, that show how spectral CT can enhance pre-clinical and medical imaging. Our primary challenge for the future is to improve our reconstruction methods to generate artefact free, quantitative material volumetric datasets for clinical use.
- Niels de Ruiter
- MARS Bioimaging Ltd, New Zealand
- Philip Butler
- MARS Bioimaging Ltd, New Zealand
- Anthony Butler
- MARS Bioimaging Ltd, New Zealand
- Stephen Bell
- MARS Bioimaging Ltd, New Zealand
- Alexander Chernoglazov
- MARS Bioimaging Ltd, New Zealand
- Michael Walsh
- MARS Bioimaging Ltd, New Zealand
- S. M. Jorgensen, A. J. Vercnocke, D. S. Rundle, P. H. Butler, C. H. McCollough, and E. L. Ritman, “Evaluation of a photon counting Medipix3RX CZT spectral x-ray detector,” Proc SPIE Int Soc Opt Eng, Oct 2016.
- N. Welding. (2015) The transformation of cancer imaging: From shades of gray to living color. Website. University of Notre Dame. [Online]. Available: http://news.nd.edu/news/the-transformation-of-cancer-imaging-from-shades-of-gray-to-living-color/
- Medipix. Welcome to the medipix homepage! Website. CERN. [Online]. Available: https://medipix.web.cern.ch/medipix/index.php
- R. K. Panta, M. F. Walsh, S. T. Bell, N. G. Anderson, A. P. Butler, and P. H. Butler, “Energy calibration of the pixels of spectral x-ray detectors,” IEEE Transactions on Medical Imaging, vol. 34, no. 3, pp. 697–706, March 2015.
- Advacam. (2017) Advacam imaging the unseen. Website. Advacam. Advacam Oy, Tietotie 3, 02150 Espoo, Finland. [Online]. Available: http://advacam.com/en/
- REDLEN. (2017) About redlen. Website. Redlen Technologies. Redlen Technologies, 123 1763 Sean Heights, Saanichton, BC, V8M 0A5. [Online]. Available: http://redlen.ca/
- DICOM Part 3: Information Object Definitions, National Electrical Manufacturers Association Std., 2014b. [Online]. Available: http://medical.nema.org/medical/dicom/current/output/html/part03.html
- zSpace. (2017) The ultimate learning experience. Website. zSpace, Inc. 490 De Guigne Drive, Ste 200, Sunnyvale, CA 94085. [Online]. Available: https://zspace.com/
- R. Aras, Y. Shen, and A. Noor, “Quantitative assessment of the effectiveness of using display techniques with a haptic device for manipulating 3d objects in virtual environments,” Advances in Engineering Software, vol. 76, pp. 43 – 47, 2014. [Online]. Available: http://www.sciencedirect.com/science/article/pii/S0965997814000933
- V. B. H. Mandalika, A. Chernoglazov, M. Billinghurst, C. Bartneck, M. Hurrell, N. de Ruiter, A. Butler, and P. Butler, “A hybrid user interface improving radiological diagnosis,” In Preparation, 2017.
- R. Zainon, J. P. Ronaldson, T. Janmale, N. J. Scott, T. M. Buckenham, A. P. H. Butler, P. H. Butler, R. M. Doesburg, S. P. Gieseg, J. A. Roake, and N. G. Anderson, “Spectral ct of carotid atherosclerotic plaque: comparison with histology,” European Radiology, vol. 22, no. 12, pp. 2581–2588, 2012. [Online]. Available: http://dx.doi.org/10.1007/s00330-012-2538-7
- R. Aamir, A. Chernoglazov, C. J. Bateman, A. P. H. Butler, P. H. Butler, N. G. Anderson, S. T. Bell, R. K. Panta, J. L. Healy, J. L. Mohr, K. Rajendran, M. F. Walsh, N. J. A. de Ruiter, S. P. Gieseg, T. Woodfield, P. F. Renaud, L. Brooke, S. Abdul-Majid, M. Clyne, R. Glendenning, P. J. Bones, M. Billinghurst, C. Bartneck, H. Mandalika, R. Grasset, N. Schleich, N. Scott, S. J. Nik, A. Opie, T. Janmale, D. N. Tang, D. Kim, R. M. Doesburg, R. Zainon, J. P. Ronaldson, N. J. Cook, D. J. Smithies, and K. Hodge, “MARS spectral molecular imaging of lamb tissue: data collection and image analysis,” Journal of Instrumentation, vol. 9, no. 02, p. P02005, 2014. [Online]. Available: http://stacks.iop.org/1748-0221/9/i=02/a=P02005
- K. Rajendran, C. Lobker, B. S. Schon, C. J. Bateman, R. A. Younis, N. J. A. de Ruiter, A. I. Chernoglazov, M. Ramyar, G. J. Hooper, A. P. H. Butler, T. B. F. Woodfield, and N. G. Anderson, “Quantitative imaging of excised osteoarthritic cartilage using spectral CT,” European Radiology, vol. 27, no. 1, pp. 384–392, Jan 2017.
- M. Moghiseh, R. Aamir, R. K. Panta, N. J. A. de Ruiter, A. I. Chernoglazov, J. L. Healy, A. P. H. Butler, and N. G. Anderson, “Discrimination of multiple high-Z materials by multi-energy spectral CT a phantom study,” JSM Biomed Imaging Data Pap, vol. 3, no. 1, p. 1007, 2016.
- H. M. Hudson and R. S. Larkin, “Accelerated image reconstruction using ordered subsets of projection data,” IEEE Transactions on Medical Imaging, vol. 13, no. 4, pp. 601–609, Dec 1994.
- C. O. Schirra, E. Roessl, T. Koehler, B. Brendel, A. Thran, and R. Proksa, “Maximum likelihood CT reconstruction from materialdecomposed sinograms using fisher information,” in 2011 IEEE Nuclear Science Symposium Conference Record, Oct 2011, pp. 4063–4065.
- R. A. Nasirudin, R. Tachibana, J. J. Nppi, K. Mei, F. K. Kopp, E. J. Rummeny, H. Yoshida, and P. B. Nol, “A comparison of material decomposition techniques for dual-energy CT colonography,” Proc SPIE Int Soc Opt Eng, 2015.
- K. Rajendran, M. F. Walsh, N. J. A. de Ruiter, A. I. Chernoglazov, R. K. Panta, A. P. H. Butler, P. H. Butler, S. T. Bell, N. G. Anderson, T. B. F. Woodfield, S. J. Tredinnick, J. L. Healy, C. J. Bateman, R. Aamir, R. M. N. Doesburg, P. F. Renaud, S. P. Gieseg, D. J. Smithies, J. L. Mohr, V. B. H. Mandalika, A. M. T. Opie, N. J. Cook, J. P. Ronaldson, S. J. Nik, A. Atharifard, M. Clyne, P. J. Bones, C. Bartneck, R. Grasset, N. Schleich, and M. Billinghurst, “Reducing beam hardening effects and metal artefacts in spectral CT using Medipix3RX,” Journal of Instrumentation, vol. 9, no. 03, p. P03015, 2014. [Online]. Available: http://stacks.iop.org/1748-0221/9/i=03/a=P03015